Pfizer · 22 hours ago

Postdoctoral Fellow, Alternative Technologies & Imaging

United States - Washington - Remote

Full-time

Remote

Entry Level

$61K/yr - $102K/yr

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BiotechnologyHealth Care

No H1B

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Responsibilities

Establish in vitro systems using liver iPSC or primary hepatic cell cultures to develop tools that can recapitulate ADC-cell interactions that occur in-vivo

Through the development and implementation of in vitro technologies, mechanistic hypothesis will be explored to define the structural characteristics of ADCs that contribute to pharmacologically undesirable interactions with liver cells that ultimately influence clearance and downstream toxicities.

In vitro finding will be further confirmed by testing hypotheses in vivo pre-clinical models.

Driving innovation, independent thinking, problem solving, and meticulous design, execution and interpretation of experiments under minimal supervision.

Collaborating and seeking guidance from subject matter experts, including toxicologists, complex cell culture specialists, cancer biologists, and protein scientists, to achieve project objectives.

Working with mentors to develop and apply complex in vitro assays to develop translatable models.

Presenting the research work at various internal and external meetings and conferences and publish in relevant peer-reviewed journals.

Contributing to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and neurotoxicology expertise.

Ensuring all tasks and responsibilities are carried out according to scientific, ethical and regulatory standards.

Qualification

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. in cell biologyMolecular biology techniquesCell culture techniques3D IPSC culturesMicrophysiologic systemsHepatic physiologyPharmacology principlesToxicology principlesMouse handlingScientific publications

Required

Ph.D. in cell and molecular biology or related fields. No more than 2 years of post-degree experience

Demonstrated experience in diverse cellular, biochemical and molecular laboratory techniques with strong background in cell biology

Possess experience using 3D IPSC or primary non-tumor cell cultures and/or microphysiologic systems

Well organized, self-motivated, team-oriented with ability to multitask with high attention to detail

Strong collaborative spirit and communication skills

Successful record of scientific accomplishments as indicated by scientific publications and/or presentations. At least one first-author publication in peer-reviewed scientific journals

Willingness to make a minimum 2-year commitment