Mount Sinai Health System · 3 days ago

Postdoctoral Fellow-MSH-30025-233

United States

Internship, Full-time

Remote

Intern/New Grad

$72K/yr - $80K/yr

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Responsibilities

Targeting cancer stem cells (CSCs) is crucial for effective cancer treatment. However, the molecular mechanisms underlying resistance to LGR5+ CSCs depletion in colorectal cancer (CRC) remain largely elusive. As part of this post-doctoral project the candidate will explore the role of oncofetal (OnF) reprogramming of the LGR5+ stem cells (SCs) in the context of WNT-driven CRC lineage plasticity. Drug and genetic screening will be initiated to uncover targetable vulnerabilities in CRC.

Organoid and mouse work.

Multiomics NGS techniques

Molecular/mechanistic experimental design and execution.

Qualification

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Organoid cultureMultiomics NGS techniquesIntestinal tumorigenesisMolecular experimental designMechanistic experimental execution