Mount Sinai Health System · 15 hours ago

Postdoctoral Fellow-MSH-30025-237

United States

Full-time

Remote

Entry Level

$72K/yr - $80K/yr

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Responsibilities

The research study focuses on functional genomics and mouse models to understand the consequences of genetic and epigenetic alterations in lung cancer.

You will participate in research to achieve a systematic and comprehensive understanding of the mechanisms of DNA repair, DNA damage responses, phenotypic plasticity, immune regulatory pathways, and immune escape mechanisms in human malignancies with a primary focus on lung cancer.

You will employ in vitro and in vivo models of lung cancer, multiple high-throughput screening technologies, genomics, proteomics, CRISPR engineering, and clinical samples to assess DNA repair, DNA damage responses, and immune sensing pathways, and evaluate their effects on therapeutic response.

You will apply advanced molecular assays including CRISPR screening, immunological analysis, pharmacological evaluations, single-cell RNAseq, and/or spatial transcriptomics to provide critical insights into the molecular circuitry that drives lung cancers and, consequently, results in the development of novel therapeutic strategies for the clinically relevant molecular subsets of lung cancer.

Qualification

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DNA repairDNA damage responsesCRISPR engineeringPhenotypic plasticityImmune regulatory pathwaysImmune escape mechanismsVitro modelsVivo modelsHigh-throughput screeningGenomicsProteomicsSingle-cell RNAseqSpatial transcriptomicsImmunological analysisPharmacological evaluations