Merck · 2 days ago

Postdoctoral Research Fellow Program, Quantitative Biosciences

South San Francisco, CA

Full-time

Hybrid

Intern Level

$75K/yr - $86K/yr

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Comp. & Benefits

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Responsibilities

Launch an independent research project using organotypic models to study cardiometabolic disease pathogenesis and therapeutic hypotheses.

Experiment with cutting-edge technologies (microfluidics, bioprinting, lab automation) to drive 3D in vitro/ex vivo cellular model development.

Collaborate with an interdisciplinary team to probe novel disease mechanisms and support drug discovery efforts.

Qualification

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Endothelial Cell BiologyAssay DevelopmentOrganotypic Models Vitro ModelsExperimental DesignData AnalysisProblem-SolvingCommunication3D Image AcquisitionAI/ML Data AnalysisBarrier Function MeasurementMolecular Biology TechniquesGenetic ManipulationImmunohistochemical ExperienceHistology ExperiencePharmacology Principles

Required

A Ph.D. in biological sciences, including cellular biology/pharmacology, biomedical engineering, genetics, or a related scientific discipline. Candidates who are expected to earn a Ph.D. within the 2024 calendar year shall be considered.

Relevant background in endothelial cell biology and assay development utilizing primary and/or iPSC derived cells.

Expertise in building and evaluating organotypic in vitro models such as co-cultures, 3D spheroids or organoids, microphysiological systems, etc.

Ability to independently design and execute complex biological experiments using a wide range of methods and techniques.

Highly skilled in scientific data documentation, analysis, and interpretation.

Ability to collaborate across disciplines and communicate effectively for both internal and external publications.

Preferred

Prior experience with 3D image acquisition (confocal or high-content imagers) and AI/ML assisted data analysis (Harmony, Columbus, ImageJ, MATLAB, etc.)

Familiarity with barrier function measurement techniques such as TEER.

Molecular biology techniques such as qPCR, western blot, cloning, etc.

Genetic manipulation of cells via transfection, CRISPR, viral integration, etc.

Immunohistochemical or histology experience.

Understanding of basic pharmacology principles.