124 applicants
Mammoth Biosciences · 3 days ago
Principal Scientist - CRISPR Gene Off-Targeting Specificity
Brisbane, CA
Full-time
Onsite
Senior Level
$155K/yr - $188K/yr
4+ years exp
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Responsibilities
Lead and conduct in-depth research to investigate off-target effects associated with Mammoth nucleases across various cell types and organisms. Design and execute experiments to characterize off-target events of DSB and non-DSB technologies and identify novel strategies to minimize them effectively
Develop, test, and optimize Mammoth’s gene-editing tools to enhance on-target specificity and reduce off-target cleavage
Analyze complex genomic datasets, employing bioinformatics tools and computational methods to identify and annotate off-target sites. Interpret data and draw meaningful conclusions to guide further research efforts
Design and oversee validation studies to assess the efficacy and safety of newly developed CRISPR reagents and protocols in relevant biological systems. Validate protocols for regulatory submissions
Collaborate closely with cross-functional teams, including molecular biologists, cell biologists, bioinformaticians, to integrate off-target findings into ongoing research projects and therapeutic programs
Stay updated with the latest advancements in CRISPR and genome-editing technologies. Attend scientific conferences, present research findings, and publish in reputable peer-reviewed journals
Ensure compliance with all relevant regulatory guidelines and ethical standards concerning genome editing and gene therapy
Qualification
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Required
Ph.D. in Molecular Biology, Genetics, Biochemistry, or a related field with a strong focus on genome editing technologies
4 years minimum of industry experience for Sr. Scientist; 6 years minimum experience (can be combination of post-PhD academic and industry) for Principal Scientist
Proven expertise in gene editing technology, with a specialization in off-target analysis and optimization
4 years experience in experimental design, execution, and data analysis related to genome editing and molecular biology techniques
3 years experience leading and mentoring scientists and collaborating cross functionally
Preferred
Experience in utilizing bioinformatics tools and software for the analysis of genomic data and CRISPR off-target prediction
Strong track record of scientific publications and contributions to the field of genome editing
Excellent problem-solving skills and a passion for innovation in gene-editing technologies
Strong written and verbal communication skills, demonstrated by the ability to present complex scientific concepts to technical and non-technical audiences
Benefits
Company-paid health/vision/dental benefits
Unlimited vacation and generous sick time
Company-sponsored meals and snacks
Wellness, caregiver and ergonomics benefits
Company
Mammoth Biosciences
Mammoth Biosciences develops novel CRISPR applications for disease detection, research, agriculture, biodefense, and more.
51-200 employees
H1B Sponsorship
Mammoth Biosciences has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Trends of Total Sponsorships
2023 (2)
2022 (3)
2021 (4)
2020 (1)
Funding
Current Stage
Late StageTotal Funding
$264.55MKey Investors
Redmile GroupNational Institutes of HealthDecheng Capital
2021-09-09Series D· $150M
2020-11-04Series C· $45M
2020-07-31Grant· Undisclosed
Leadership Team
Trevor Martin
Co-Founder and CEO
Janice Chen
Co-Founder, Chief Technology Officer
Recent News
2024-05-23
2024-05-23
Company data provided by crunchbase
