National Black MBA Association · 2 days ago

Research Scientist II/Senior Scientist I, Biologics Engineering & Assays

San Diego, CA

Full-time

Onsite

Senior Level

$80K/yr - $120K/yr

5+ years exp

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Responsibilities

Design and make different types of biologics (antibodies, conjugates, bispecific antibodies etc) using molecular biology tools.

Coordinate or execute expression and purification of biologics and be accountable for interpreting analytical results to maintain quality of outputs.

Conduct functional assays, including generating and maintaining stable cell lines.

Contribute to analysis and synthesis of results, design of new experiments and clear communication of scientific progress to project team(s); troubleshoot experiments and suggest mitigation strategies.

Work effectively as a member of cross-functional teams to accomplish shared project goals.

Contemporaneous and accurate documentation in sample databases and electronic notebooks

Qualification

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Mammalian cell cultureAseptic techniqueExperiment designData analysisMolecular biology techniquesPlasmid constructs designDNA softwareProtein biochemistry techniquesSDS-PAGEAntibody purificationProtein purificationBiophysical measurementsAttention to detailEagerness to learnAntibody CharacterizationCell Line GenerationCell-Based AssaysProtein LabelingAntibody ConjugationFlow CytometryELISASPR Binding MeasurementsExperiment AnalysisExcelMacro ProgrammingPrismSpotfireFlowJoOctet

Required

BS or MS degree in biology, biochemistry, molecular biology, or related discipline with at least 2+ years of relevant academic or industry laboratory experience

Experience with mammalian cell culture and a solid understanding of best practices for aseptic technique

Excellent technical ability, attention to detail, and an eagerness to learn new things

Proficiency in designing and conducting experiments, and to analyze, interpret and communicate data

Knowledge of molecular biology techniques for the design and generation of plasmid constructs for protein expression and use of standard DNA software (eg Lasergene, Snapgene, Vector NTI)

Experience with standard protein biochemistry techniques such as SDS-PAGE, antibody and protein purification, and familiarity with interpretation of biophysical measurements