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Company

Original Job Post

myGwork - LGBTQ+ Business Community · 3 days ago

Senior Scientist, Molecular Pharmaceutics, Drug Product Design

San Diego, CA

Full-time

Onsite

Senior Level

$88K/yr - $147K/yr

7+ years exp

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Responsibilities

Evaluate the physicochemical properties of potential small molecule drug candidates to inform a drug product formulation strategy and developability risk assessment

Design and develop fit for purpose and diagnostic traditional and enabled formulations for preclinical studies

Become a subject matter expert in formulation and process development for SDDs supporting multiple discovery teams across several research units

Design, execute, and interpret the results of polymorph and salt screens for potential drug candidates related to stability, manufacturability, and bio-performance

Apply first principles understanding of thermodynamics and kinetic processes to dissolution and precipitation of drugs in biorelevant conditions and physical and chemical stability in the solid state.

Work in cross-disciplinary teams and partner with subject matter experts in Medicinal Chemistry, Pharmacokinetics & Drug Metabolism, and Clinical Pharmacology departments to influence candidate selection and progression. Develop strategic collaborations with academic and industrial researchers for addressing gaps in fundamental or applied science related to the pharmaceutical sciences

Conduct novel research and present significant findings via internal and external presentations or publications

Qualification

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Laboratory ExperienceCollaborationFormulationManufacturingBioavailability enhancementExperimental designData interpretationMathematical modelingPharmacokinetic modelingFormulation designPreclinical studiesDrug product designGastroplusProject managementLaboratory proceduresData analysisSafe work practicesPersonal Protective EquipmentOrganizational skillsInterpersonal skillsTeamwork skillsWritten communication skillsVerbal communication skills

Required

Recent PhD with 1-3 year post-doctoral experience, MS with 7+ years experience, or BS with 8+ years experience in Chemical Engineering, Physical Chemistry, Biophysical Chemistry, Biophysics, Physics, Physical Organic Chemistry, Pharmaceutics, Pharmaceutical Sciences or Biochemistry

Candidates with experience in allied disciplines may also apply with the following qualifications: Ph.D. with minimum 3 years, MS with 7+ years, or BS with 12+ years of experience in industry

Experience working independently and collaboratively in a laboratory environment

Preferred

Experience in formulation and manufacturing of SDDs targeted at bioavailability enhancement

Experience in breaking down and isolating the controlling physics of complex processes for experimental design

Experience in designing and conducting hypothesis driven laboratory experiments

Generating, interpreting, and integrating experimental data into mathematical models to progress the understanding of complex materials and processes

Experience in pharmacokinetic modeling and simulations using Gastroplus or similar modeling software

Experience with formulation design for preclinical studies as well as awareness of drug product design criteria for phase 1 clinical trials

Strong organizational skills, interpersonal skills, teamwork skills, strong written and verbal communication skills

Ability to prioritize and manage multiple projects and activities while managing tight timelines

Includes activities in both laboratory and office settings which would require varying degrees of sitting, standing, moving about the workspace, light lifting, working at a computer, and performing routine laboratory tests and procedures. Also requires the ability to perform mathematical calculations and complex data analysis.

Occasional travel may be requested. Laboratory work requires adherence to safe work practices and procedures such as use of Personal Protective Equipment (gowning, gloves, protective eyewear, etc).