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Septerna · 2 days ago
Senior Staff Scientist/Associate Director, Disease Biology and Translational Sciences
South San Francisco, CA
Full-time
Onsite
Senior Level, Director
$175K/yr - $200K/yr
8+ years exp
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Responsibilities
Design and execute in vitro and ex vivo studies to advance therapeutic programs
Generate, analyze, and interpret complex data to establish functional PK/PD and efficacy relationships and elucidate therapeutic mechanism of action for lead drugs
Serve as Disease Biology lead on multiple project teams, conduct and trouble-shoot experiments, analyze and interpret data, and work cross-functionally with colleagues to identify and mitigate risks and effectively advance therapeutic programs
Help build complex in vitro and ex vivo research and development capabilities
Author and review protocols, study reports, and regulatory documents to enable IND and other regulatory filings
Follow all company policies/practices, and maintain accurate records and notebooks
Qualification
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Required
PhD in Endocrinology, Physiology, Diabetes/Obesity, Immunology/Inflammation, or Metabolic Disease, or related biological science (MSc/BSs with relevant years of experience)
At least 8 years direct hands-on experience in therapeutic development leveraging indication specific functional disease models in biotechnology and pharmaceutical industries (MSc with at least 12 years, BSc with at least 14 years)
Experience with cell-based assays, ELISA, MSD, qPCR, RNA-seq, microscopy, histology/pathology (e.g. IF/IHC/ISH), and/or flow cytometry
Direct experimental experience with complex disease biology of diabetes, obesity, or other metabolic disease
Demonstrated expertise in building PK/PD and efficacy relationships with complex 2D/3D functional cell-based and tissue-based assays
Leverage complex data sets to characterize therapeutic leads and establish a drug’s therapeutic mechanisms of action
Experience working on/leading project teams with functional responsibility to propose strategy, analyze, interpret, and present complex data to inform decisions
Ability to collaborate in writing protocols, reports, and regulatory documents
Experience working with vendors and CROs to execute studies, analyze data, and generate reports in a timely manner
Experience authoring study protocols, reports, and/or regulatory documents including IBs, IND filings, CSRs, and/or NDAs
Outstanding communication skills with demonstrated ability to make effective presentations in a broad range of settings
Detail-oriented and organized, with strong interpersonal skills for clear and effective communication
Preferred
Experience with therapeutics programs which have yielded drugs entering clinical development in one or more of the following therapeutic areas: endocrinology, diabetes/obesity, immunology/inflammation, or metabolic disease
Experience with microscopy, confocal imaging, or similar a plus
Experience working as a subject matter expert with complex cell-based 2D/3D culture systems or ex vivo tissue models or patient-derived samples a plus
Ability to generate, analyze and interpret multi-omic data sets
Establish workflows, use Jupyter notebook or other platform to perform bioinformatics analysis and interpret and visualize complex data sets a plus
Previous work leading a program in therapeutic discovery/development
Strong statistical analysis skills and an ability to articulate findings and make recommendations from complex study results
Experience mentoring scientists, leading cross-functional project teams, and a track record of successful management of external teams
Benefits
Benefits
Stock Options
Annual Target Bonus
Company
Septerna
Septerna is a biotech firm unlocking diverse drug discovery potential in G protein-coupled receptors across various diseases.
51-200 employees
H1B Sponsorship
Septerna has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Trends of Total Sponsorships
2022 (1)
Funding
Current Stage
Growth StageTotal Funding
$250MKey Investors
RA Capital ManagementThird Rock Ventures
2023-09-12Acquired· by Vertex Pharmaceuticals
2023-07-11Series B· $150M
2022-01-27Series A· $100M
Leadership Team
Jeffrey Finer
Chief Executive Officer and Co-Founder
A
Arthur Christopoulos
Co-Founder
Recent News
2024-05-28
BioWorld MedTech
2024-04-10
Company data provided by crunchbase
