Frontier Medicines · 2 days ago

Sr. Scientist, Disease Biology

South San Francisco, CA

Full-time

Onsite

Senior Level

$128K/yr - $182K/yr

5+ years exp

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Responsibilities

Opportunity to be a functional team lead accountable for timely delivery of team objectives, collaborating effectively to ensure best practices within disease biology function and across teams. Influences other teams by maintaining communication across teams.

Design, execute, and analyze key biological experimental strategies to define drug mechanism of action, develop novel disease models and biomarkers for target engagement and patient selection with a high level of independence and creativity.

Lead and contribute to target selection and target validation to ensure the development of a robust preclinical pipeline of valuable drug discovery programs.

Contribute to project teams and the preclinical development of lead assets to achieve project deliverables.

Effectively communicate with colleagues and stakeholders; create and present research updates and provide strategic input to team/company meetings.

Coordinate with external contract research organizations and with other collaborators, as needed.

Maintain a clear, detailed laboratory notebook to document all experiments and findings.

Comply with best laboratory safety practices.

Qualification

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Cancer biologyOncology drug discoveryAssay designCell engineeringCRISPRSiRNAFACSELISAImmuno-blottingHigh-throughput assaysTechnical writingProblem-solvingCommunicationOrganizationFast learner

Required

Ph.D. in a biological science (biochemistry, molecular biology, cellular biology, bioengineering, or related discipline), with at least 5 years of relevant post-graduate and pharma/biotech experience

Experience in cancer biology, working in oncology drug discovery project teams, cancer cell-based assay design, assay development and drug testing

Experience with mammalian tumor cell engineering and associated techniques including CRISPR and siRNA/shRNA knockdown

Experience with cellular and biochemical techniques, including FACS, ELISA, immuno-blotting, and high-throughput cellular assays

Excellent communication, organization, and technical writing skills

Self-motivated and enthusiastic; fast learner who can identify core project challenges and expeditiously change course as required in a fast-paced organization

Exceptional oral communication and writing skills

Legally authorized to work in the US