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Septerna · 2 days ago
Staff Scientist, Translational Sciences
South San Francisco, CA
Full-time
Onsite
Senior Level
$140K/yr - $160K/yr
5+ years exp
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Responsibilities
Design and execute in vitro, in vivo, and ex vivo studies for translational biomarker strategies
Generate, analyze, and interpret complex data for PK/PD, efficacy, and safety relationships
Serve as Translational Sciences lead on project teams and troubleshoot experiments
Build biomarker discovery and development capabilities
Author and review protocols, study reports, and regulatory documents
Follow company policies/practices and maintain accurate records
Qualification
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Required
PhD Endocrinology, Pharmacology, Toxicology, Immunology / Inflammation, or Metabolic Disease, or related biological science
At least 5 years direct hands-on experience in therapeutic development leveraging (complex) in vitro and in vivo disease models for biomarker discovery and development in biotechnology and pharmaceutical industries
Ability to be hands on and working in the lab, write protocols, execute studies leveraging Septerna in house capabilities or working with CROs
Direct experimental experience with pharmacology models or disease biology and demonstrated expertise in PK/PD, efficacy, and cell and tissue-based biomarker discovery
Direct experience for analysis and interpretation of multi-omics and complex data sets such as bulk or scRNAseq to inform biomarker discovery and therapeutic MOA
Experience with clinical biomarker development (pharmacodynamic, predictive, and safety) to inform clinical translation and patient selection strategies
Experience working on/leading project teams with functional responsibility to analyze, interpret, and present complex data to inform strategic decisions
Ability to collaborate in writing protocols, reports, and regulatory documents
Experience working with vendors and CROs to execute studies, analyze biomarker data, and generate formal reports
Experience authoring in vivo study protocols, reports, and/or regulatory documents including IND filings, CSRs, and/or NDAs
Outstanding communication skills with demonstrated ability to make effective presentations in a broad range of settings
Detail-oriented and organized, with strong interpersonal skills for clear and effective communication – ability to proactively engage and collaborate with colleagues for effective decision-making in a fast-paced, team-oriented environment
Preferred
Experience with therapeutics programs which have yielded drugs entering clinical development in one or more of the following therapeutic areas: endocrinology, Immunology / Inflammation, or Metabolic Disease
Experience working with complex cell-based systems or ex vivo models or patient samples to generate multi-omic data
Establish workflows, use Jupyter notebook or other platform to perform bioinformatics analysis and interpret and visualize complex data sets a plus
Previous work leading a program in therapeutic discovery/development or toxicology
Strong statistical analysis skills and an ability to articulate findings and make recommendations from complex study results
Experience mentoring scientists, leading cross-functional project teams, and a track record of successful management of external teams
Benefits
Stock options
Annual target bonus
Company
Septerna
Septerna is a biotech firm unlocking diverse drug discovery potential in G protein-coupled receptors across various diseases.
51-200 employees
H1B Sponsorship
Septerna has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Trends of Total Sponsorships
2022 (1)
Funding
Current Stage
Growth StageTotal Funding
$250MKey Investors
RA Capital ManagementThird Rock Ventures
2023-09-12Acquired· by Vertex Pharmaceuticals
2023-07-11Series B· $150M
2022-01-27Series A· $100M
Leadership Team
Jeffrey Finer
Chief Executive Officer and Co-Founder
A
Arthur Christopoulos
Co-Founder
Recent News
2024-05-28
BioWorld MedTech
2024-04-10
Company data provided by crunchbase
